4 eggs retrieved how many fertilized

The more chromosomally normal embryos there are, the more transfers are possible, with an inevitably better cumulative chance of pregnancy and live birth. Chromosomally abnormal aneuploid embryos are unlikely to develop as pregnancies, and, if they do, sadly frequently result in miscarriage. A number of studies 1, 2 published recently suggest that cumulative live IVF birth rates increase significantly with the number of eggs retrieved.

This association is not evident in the initial fresh cycle of treatment, where birth rates might be even inferior when a high number of oocytes is obtained 1, 3. This is most likely due to an adverse effect of intense ovarian stimulation on the receptivity of the endometrium as has been convincingly demonstrated 4, 5. This study also provides evidence that aiming for a higher egg yield during ovarian stimulation does not seem to compromise the quality of the eggs obtained.

This has been debated for years but recently accumulated evidence suggests that a detrimental effect of intense ovarian stimulation on egg quality is unlikely. On the contrary, obtaining a higher number of eggs will probably lead to a higher number of competent eggs and, as the present study has shown, to more chromosomally normal euploid embryos. While this study does provide strong evidence in the ongoing debate over the importance of egg numbers as determinants of IVF success, any attempt to propose an optimum number of egg collected needs to take into account many other parameters such as:.

It should not be overlooked that aiming for a high number of eggs usually more than 15 can increase the risk of ovarian hyperstimulation syndrome OHSS , a potentially serious complication of ovarian stimulation. However, newer IVF protocols can substantially reduce this risk, allowing fertility specialists to maximize the results from a single IVF cycle and thereby reduce the financial, physical and emotional cost of fertility treatment. Increasing the oocyte yield should always be performed safely which means an individualised approach should be discussed with your fertility specialist.

Patients wishing to know more about this study, including how to increase their chance of pregnancy from IVF treatment, should speak with their local fertility specialist:. The optimum number of oocytes in IVF treatment: an analysis of cycles in China. If the treatment requires ICSI, each of the mature eggs will be injected with a single washed sperm. Immature eggs will not be injected. Egg mass immediately following egg retrieval procedure. The dark circle in the centre is the egg.

The eggs are examined first thing in the morning and then a second time later in the morning. Fertilization cannot be classified as normal if these structures are not seen.

Sometimes only one nucleus is seen or there are more than two of these nuclei seen. Only those eggs that show normal fertilization i. Egg with normal fertilization Egg with abnormal fertilization. One of the embryologists will send a portal message with the results of the fertilization. One of the embryologists will send a portal message with the Day 2 results. On Day 2, the embryos should have started to grow and should have divided to form an embryo of 2 cells to 4 cells. The important milestone for Day 2 is that the embryos have progressed from the 1-cell, fertilized egg stage to an embryo with 2 or more cells.

In addition to the stage of growth, the embryos will each receive a grade from 1 to 5 1 being the best quality and 5 being the lowest quality. On average, most embryos are grades 2 and 3.

Embryos will sometimes have grades 4 and 5. The grade does not determine the ultimate fate of the embryo. Many grade 4 embryos can successfully form blastocysts and therefore all grades of embryos are always kept in culture. Grade 5 embryos usually indicate that the embryo is not surviving or it is not growing as it should. Good quality 4-cell embryo grade 2 , with cells blastomeres of slightly different sizes.

This is an example of a grade 2 embryo. It is expected that most embryos will have divided to have 6 to 8 cells on Day 3, however it is not unusual to have some that are slightly slower or some that are more advanced.

As long as the embryos are of average to good quality grades and have grown since Day 2, there is usually no cause for concern. The embryos will again receive a grading from 1 to 5 on Day 3. Remember, the grade does not necessarily predict the ultimate fate of the embryo.

The cohort of embryos is progressing well if the embryos are mostly in the grades 1 to 3 range. One of the embryologists will provide an update via the portal regarding the Day 3 embryo progress. Excellent quality Day 3 embryo with 7 cells present. This is an example of a grade 1 embryo. The embryos should have developed to have 10 cells or more on Day 4. It is important to know that it is not unusual to lose up to half of the average to good quality embryos from Day 3 to day 4.

This is because of the complex changes occurring in the embryo at this stage of development. One of the embryologists will send a portal message to update on the progress and development of the embryos. If there will be a fresh embryo transfer, the embryologist will also include in the message, the appointment time for the embryo transfer the next day. For patients who have chosen preimplantation genetic testing, the embryologists may call on Day 4 if an embryo transfer instead of embryo biopsy might occur only for PGT patients on luteal support medication.

On Day 5 the expectation is that a proportion of the embryos have begun to form blastocysts. For patients having a fresh embryo transfer, the embryologists will not send a message today. The progression and quality of the embryos will be discussed just prior to the embryo transfer procedure. The number of embryos that are genetically normal is completely dependent on the age and genetic material of the egg and sperm. Once an embryo is transferred, the nail-biting wait for a hopeful BFP big fat positive pregnancy test result begins.

I personally have never been able to wait and have done home tests every time starting five days after the transfer. There are many factors, including chance, that determine if an embryo will implant. Shady Grove Fertility reports that women under 35 years of age have over a 60 percent chance of pregnancy per transfer. It has also been shown that not all doctors are equally competent at performing embryo transfers, and success rates can depend on the doctor performing the procedures.

In addition to genetic testing, there is a strong correlation between blastocyst morphology and implantation. The morphology of an embryo is the shape or appearance of cells in the embryo. One observational study of 1, single embryo transfers showed that:. Most clinics will provide pictures of the embryo, as well as its grading. A beta hCG level of over is generally considered a good, positive result.

But many successful pregnancies do start out with a lower beta hCG level. But w hat's more important than the absolute beta number is if the number increases substantially over time it should double every 48 hours. A beta that fails to double, or one that decreases over time, nearly always indicates a failed pregnancy. Other factors that impact the chances of miscarriage after IVF include a high BMI, an embryo biopsy on Day 6, and a high number of previous miscarriages. Miscarriage is devastating.

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